HelP-T2D: Helminth products for Type 2 Diabetes

HelP-T2D publications

Guigas B and Molofsky A.B.
A worm of one’s own: how helminths modulate host adipose tissue function and metabolism.
2015. Review. Trends in Parasitology, in press

Hussaarts L, Garcia-Tardon N, van Beek L, Heemskerk MM, Haeberlein S, van der Zon GC, Ozir-Fazalalikhan A, Berbee JF, Willems van Dijk K, van Harmelen V, Yazdanbakhsh M, Guigas B.
Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice.
2015. FASEB J, 29(7):3027-39

Scientific background of the project

Wiria AE, Hamid F, Wammes LJ, Prasetyani MA, Dekkers OM, May L, Kaisar MM, Verweij JJ, Guigas B, Partono F, Sartono E, Supali T, Yazdanbakhsh M, Smit JW.
Infection with Soil-Transmitted Helminths Is Associated with Increased Insulin Sensitivity.
2015. PLoS One, 10(6):e0127746.

Wiria AE, Sartono E, Supali T, Yazdanbakhsh M.
Helminth infections, type-2 immune response, and metabolic syndrome.
2014. PLoS Pathog., 10(7):e1004140.

Hussaarts L, Yazdanbakhsh M, Guigas B.
Priming dendritic cells for Th2 polarization: lessons learned from helminths and implications for metabolic disorders.
2014. Front Immunol., 5:499.

Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM.
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
2013. J Exp Med. 11;210(3):535-49.

Yang Z, Grinchuk V, Smith A, Qin B, Bohl JA, Sun R, Notari L, Zhang Z, Sesaki H, Urban JF Jr, Shea-Donohue T, Zhao A.
Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity.
2013. Infect Immun., 81(6):1905-14.

Bosch D, Castilho A, Loos A, Schots A, Steinkellner H.
N-glycosylation of plant-produced recombinant proteins.
Curr Pharm Des. 2013;19(31):5503-12. Review.

Bhargava P, Li C, Stanya KJ, Jacobi D, Dai L, Liu S, Gangl MR, Harn DA, Lee CH.
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways.
2012. Nat Med., 18(11):1665-72.

Wiria AE, Djuardi Y, Supali T, Sartono E, Yazdanbakhsh M.
Helminth infection in populations undergoing epidemiological transition: a friend or foe?
2012 Semin Immunopathol. Nov;34(6):889-901. Epub 2012 Nov 6.

Everts B, Hussaarts L, Driessen NN, Meevissen MH, Schramm G, van der Ham AJ, van der Hoeven B, Scholzen T, Burgdorf S, Mohrs M, Pearce EJ, Hokke CH, Haas H, Smits HH, Yazdanbakhsh M.
Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor.
2012. J Exp Med., 209(10):1753-67, S1.

Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM.
Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis.
2011. Science, 332(6026):243-7.

Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A.
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity.
2010. Proc Natl Acad Sci U S A., 107(52):22617-22.